Ah, Denver!
My oldest got married there, and prior to that I made a lot of work visits to Northern Colorado in the 1990s (Ft. Collins/Loveland/Greeley area).
Denver itself I can take or leave, but the mountains are wonderful. If you have time (probably not, I would guess, but still...), a road trip to southern Utah gets you to some of the most impressive scenery in North America, IMHO. I mean the high desert and canyons of the Colorado river watershed. There's Arches and Bryce Canyon, and Zion national parks, and Kodachrome Basin state park, Escalante, and many more. Simply driving I70 out of Denver westwards is amazing and the landscape changes totally beyond Grand Junction, from mountains to high plateau.
To my shame, probably, I have, so far, never made it North to Wyoming (i.e. Yellowstone). That said, the drive up the Poudre Valley from Fort Collins to Walden is spectacular and can be done there and back in a day. That high plateau (surrounding Walden) is breathtaking too, in a different way, as it's wetland rather than the desert of S. Utah. Take binoculars, as there's lots of wildlife .
All that said, Denver's nickname is 'the mile-high city', and in the country of the internal combustion engine, that matters.. The whole Front Range is prone to sudden and unpleasant weather changes* in the winter/early spring, and there will still be a lot of snow in the mountains (and planeloads of tourists there for the skiing resorts along I70).
I generally like driving in the US, as long as the hire car is fairly high off the ground (visibility for me and other drivers seeing me!), and, for the Rockies, a decent engine and/or 4x4 capability. In my limited experience Coloradians can be truly idiotic drivers, especially the speeds they do in snow and ice ("Well, the signs said '75', so I did..."). In warmer months it's not as bad, but don't forget it's now a state where pot use is encouraged.
I don't know about food, but New Belgium Brewery's "Fat Tire" used to be excellent, as long as it wasn't served too cold (an American vice!). It's brewed up the road in Fort Collins. I note with concern though that in 2023 it was "tweaked" (brewery's own term), and is now lighter and more lager-ish, and they've changed the label design.
Also keep an eye out for "Polygamy Porter" from Wasach Brewery in Salt Lake City (tagline: "Why have just one?"). It is, of course, very more-ish...
Whatever you do, or don't do, have huge fun.
E.
* There are almost no tall buildings once you come out of Denver suburbs going northwards on I25 (at least there didn't used to be!). One of the tallest was the Ft. Collins Marriott, which, IIRC, had six or seven floors. At the top there was a guest lounge. It had a panoramic view South West, along the mountains for tens of miles with nothing in the way.
One January or February, around dusk, I checked in, found my room and, not wanting a big meal, went up to get a coffee and a pastry. Nobody was about, apart from one staff member tending the buffet. Together, for about an hour, we watched a spectacular storm work its way up the Front Range. There were big hailstones & heavy, sleety rain (basically the works), but the lightning was just amazing.
I think Americans have never 'conquered nature' -- they've just got used to it.